产品货号：
Z34760
中文名称：
MEK1/MP2K1抗体
英文名称：
Anti-MEK1/MP2K1 Antibody (Clone#1678CT373.38.18)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MEK1/MP2K1 Antibody (Clone#1678CT373.38.18) |
| 指标别名 | ERK activator kinase 1;MAP kinase kinase 1;MAP2K1;MAPK/ERK kinase 1;MAPKK 1;MAPKK1;MEK 1;MEK1;MEK1-Specific;MKK1;PRKMK1 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,FCM |
| 基因名称 | MAP2K1 |
| 克隆号 | 1678CT373.38.18 |
| 抗体来源 | Mouse |
| 免疫原 | This MP2K1 antibody is generated from a mouse immunized with a recombinant protein between 1-393 amino acids from human MP2K1. |
| 计算分子量 | 43kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway.Binding of extracellular ligands such as growth factors,cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation.RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2.Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade,and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2,leading to their activation and further transduction of the signal within the MAPK/ERK cascade.Depending on the cellular context,this pathway mediates diverse biological functions such as cell growth,adhesion,survival and differentiation,predominantly through the regulation of transcription,metabolism and cytoskeletal rearrangements.One target of the MAPK/ERK cascade is peroxisome proliferator- activated receptor gamma (PPARG),a nuclear receptor that promotes differentiation and apoptosis.MAP2K1/MEK1 has been shown to export PPARG from the nucleus.The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics,including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC),as well as in the fragmentation of the Golgi apparatus during mitosis. |
| Uniprot ID | Q02750 |
相关搜索：MEK1/MP2K1抗体，MEK1抗体，MP2K1单抗，Anti-MEK1/MP2K1 Antibody (Clone#1678CT373.38.18)